CRISPR
CRISPR Next Advance Is Bigger Than You Think Jennifer Doudna TED
https://www.youtube.com/watch?v=HANo__Z8K6s
The Age of CRISPR Engineering the Future of Genetic Medicine Benjamin Oakes TEDxBerkeley
Benjamin Oakes says:
"Now recent advances are allowing us to move more upstream in this process towards for example mRNA or utilize mRNA and the Covid vaccines of course are a good example of this but it is only recently that we finally have the ability to target the underlying code of disease or our own genome and it is only with this that we are now finally able to go from disease treatment to disease transformation, again Crispr and genome editing technologies are what is allowing us to rewrite the story of disease"
"And if you know that I'm sure you also understand that Crispr is a technology that allows us to essentially build a molecule that can target nearly any location of the genome in nearly any organism, it's incredible, it's programmable, it's efficient but what I bet you don't know is the fact that these Crispr systems are actually bacterial immune systems, they're what bacteria uses to fight off viruses and because of that they're not genome editing tools they have shortcomings, now despite this they are changing health care, they are changing agriculture, medicine, biotechnology, anything that in any way touches biology is changed by the ability of Crispr to programmably modify the genome"
Yuval Harari Noah homosexual Jew Atheist: Humans are Hackable Animals
https://www.facebook.com/watch/?v=441274723228073
Benjamin Oakes says:
"So I believe this of course, I've been working on this, I've been working on this for a very long time, I actually started out working on engineering genome editing tools for over a decade, over a decade ago back B.C. or before Crispr technology"
"Now when Jennifer published her seminal work in 2012 though I immediately saw the value in this technology and moved out to UC Berkeley to work with Jennifer Doudna as well as another UC Berkeley Professor Dave Savage in their Labs I worked on engineering a number of really interesting and unique Crispr molecules that could do all sorts of things many of which you could see here and when I graduated I became one of the first innovative genomics institutes entrepreneur fellows and in that process I honed my mission with a real focus on unlocking the potential now of genetic medicine by engineering Crispr specifically for that goal what this means is really taking these bacterial immune systems melting them down, melting down this natural material and reforging it into the more perfect genome in scalpel that can cut more specifically, more actively, could be easily, more easily delivered and our ultimate goal is to create genetic medicines that are safe and effective enough to be used at scale, no longer are we thinking just about treating rare disease but how do we bring genetic medicine to each and every one of you in a way that can more meaningfully impact your life"
"The ultimate goal here is really creating treatments that have the potential to be a standard of care, the first treatment potentially that you can get"
"And so we blueprinted a company called Scribe and an approach called 'Crispr by Design', again co-founded by myself [Benjamin Oakes], Jennifer Doudna, Dave Savage, as well as Brett Stall; and our goal has been to engineer these genome editing tools to be more potent, safe and effective"
"So what does Crispr by Design actually look like, how do we do this, how do we make a more effective genome editing tool, what we actually have done is we can look at tens of thousands to tens of millions of different possibilities, test each one, track whether or not that modification improves the system or hurts the system"
"We can then incorporate all of these changes into a single more perfect genome editing tool"
"An interesting way to think about this is that we are essentially doing holistic molecular engineering at the nano scale to transform human health at the macro scale"
"Now on the flip side of this we do understand the genetics that allow us to modify and lower bad cholesterol and if we could use that knowledge to lower LDLC by greater than 50% we could have a meaningful impact on cardiovascular disease and heart attacks globally; if we did that in the United States alone we would save over $25 billion in cost to the Health Care System each year; now at Scribe we set out to do this and lo and behold we have been quite successful by engineering Crispr tools to be more potent and safe, what we have been able to demonstrate clearly in large animal models is that we can reduce cholesterol levels by over 50% and that this treatment is stable now out for 6 months, this is exciting because this has the potential to become a new standard of care for anyone who has had a heart attack and potentially in the future who is at risk for cardiovascular disease so this is a testament to what the future of genetic medicine can look like"
"We no longer are going to be limited to just treating rare diseases which must be treated as well but also to creating standard of care treatments for the broadest diseases possible, enabling all of us to think about writing our own stories rather than just inheriting them"
"And so once again I ask how do you think that genetic medicine such as this could impact your lives or the lives of your loved ones and how do we ensure that that future comes to be; now the good news is that we are working on this each and every day to give each of us the ability to rewrite our own genetic destiny, there will be a future in which you can visit your doctor and walk out healthier I am sure of that, perhaps we even get rid of the paradigm of taking a handful of pills in the morning and a handful of pills at night, like wouldn't that be great, but to get there we have to engineer not only our own biology but the tools that allow us to engineer that biology and this is what I am deeply committed and passionate about and we are dedicated to at Scribe: Engineering a more empowered future for us all, thank you"
Bill Gates said:
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